Table 2.
Association between RA and all-cause mortality according to time period
| 1999–2006 | 2007–2014 | p for interaction | |||
|---|---|---|---|---|---|
| RA cohort (n=10 126) | Non-RA cohort (n=50 546) | RA cohort (n=10 769) | Non-RA cohort (n=53 749) | ||
| Mean follow-up (person-years) | 3.18±2.13 | 3.25±2.15 | 330±2.18 | 330±2.21 | |
| Deaths (n) | 936 | 2968 | 605 | 2293 | |
| Death rate/1000 PYs (95% CI) | 29.1 (27.2 to 30.1) | 18.0 (17.4 to 18.7) | 17.0 (15.7 to 18.4) | 12.9 (12.4–13.5) | |
| Age-matched, sex-matched and entry year-matched rate ratio (95% CI) | 1.66 (1.54 to 1.79) | 1.00 (Ref) | 1.35 (1.23 to 1.48) | 1.00 (Ref) | <0.01 |
| Multivariable-adjusted rate ratio (95% CI)* | 1.56 (1.44 to 1.69) | 1.00 (Ref) | 1.29 (1.17 to 1.42) | 1.00 (Ref) | <0.01 |
| Age-matched, sex-matched and entry year-matched rate difference/1000 PYs (95% CI) | 11.0 (9.0 to 13.0) | 0.0 (Ref) | 4.1 (2.6 to 5.6) | 0.0 (Ref) | <0.01 |
| Multivariable-adjusted rate difference/1000 PYs (95% CI)* | 9.5 (7.5 to 11.6) | 0.0 (Ref) | 3.1 (1.5 to 4.6) | 0.0 (Ref) | <0.01 |
*
In addition to the matching variables, multivariable models were adjusted for the number of GP visits, BMI, smoking status (ie, non-smokers, ex-smokers and current smokers), alcohol consumption (ie, non-drinkers, ex-drinkers and current drinkers), comorbidities and medication use prior to the index date.
BMI, body mass index; GP, general practitioner; PY, person-year; RA, rheumatoid arthritis.