Table 2. Estrogen and anti-androgen options for transgender women.

Route	Formulation	Dosing
Oral	Estradiol	2–4 mg daily
Parental (subcutaneous, intramuscular)	Estradiol valerate	5–30 mg every 2 weeks
Transdermal	Estradiol	0.1–0.4 mg twice weekly
Anti-androgens	Progesterone	20–60 mg PO daily
	Medroxyprogesterone acetate	150 mg IM every 3 months
	GnRH agonist (leuprolide)	3.75–7.5 mg IM monthly
	Histrelin implant	50 mg implanted every 12 months
	Spironolactone	100–200 mg PO daily
	Finasteride	1 mg PO daily