Table 1. Summary of purported beneficial effects of testosterone supplementation in hypogonadal males.

Symptom	Level of evidence*
Body composition, physical activity, strength
Increased lean body mass	1A
Decreased fat mass	1A
Improved bone mineral density	1A
Sexual function and libido
Improved libido	1A
Improved morning erections	1A
Improved erectile function	1A
May improve response to PDE5s in those previously refractory to PDE5s	1B−
Medical comorbidities
DM-improved fasting glucose, HbA1c, insulin sensitivity	1A
Lipids-improved TG, total cholesterol; variable results on HDL and LDL	1A−
Psychological/cognition
Inconsistent and contradictory results with mood, cognition, behavior	1B−
Potential benefit in improving depression in hypogonadal or HIV positive males	1A−

*, level of evidences is assigned by the authors based on Oxford criteria and utilizing the data provided in the current review. Reprinted: AUA Core Curriculum Sexual medicine: Hypogonadism medical treatment (https://www.auanet.org/university/core_topic.cfm?coreid=102). This table is open to all AUA members.