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A schematic representation of term and preterm pathways.
1A: Fetal signals of organ maturation and fetal tissue senescence can cause an inflammatory oxidative stress response in the intrauterine tissues, activating various pro-labor mediators like prostaglandins and endothelins to cause labor associated changes.
1B: These signals are prematurely replaced by maternal-fetal risk exposures to drive the mechanistic pathways to cause spontaneous preterm labor and or pPROM.
