Table 2. Modularity analysis.
The list of pathways enriched in modules for CSF (MS vs. controls).
| Module ID | Pathway | p-value |
|---|---|---|
| M1 | hsa04062 : chemokine signaling pathway | 7.7E–3 |
| hsa04060 : cytokine–cytokine receptor interaction | 1.5E–2 | |
| hsa04672 : intestinal immune network for IgA production | 3.8E–2 | |
| M2 | hsa05010 : Alzheimer’s disease | 3.0E–3 |
| hsa05014 : Amyotrophic Lateral Sclerosis (ALS) | 3.1E–2 | |
| hsa04720 : long-term potentiation | 4.0E–2 | |
| M4 | hsa04640 : hematopoietic cell lineage | 4.7E–6 |
| hsa04060 : cytokine–cytokine receptor interaction | 1.4E–4 | |
| hsa04210 : apoptosis | 8.6E–4 | |
| hsa05020 : prion diseases | 2.1E–2 | |
| hsa05332 : graft-versus-host disease | 2.3E–2 | |
| hsa04940 : type I diabetes mellitus | 2.5E–2 | |
| M7 | hsa00590 : arachidonic acid metabolism | 3.3E–2 |
| M9 | hsa04620 : toll-like receptor signaling pathway | 1.7E–5 |
| M13 | hsa05217 : basal cell carcinoma | 2.3E–3 |
| hsa04340 : hedgehog signaling pathway | 2.3E–3 | |
| M14 | hsa04010 : MAPK signaling pathway | 1.5E–2 |
| M15 | hsa04110 : cell cycle | 1.2E–2 |
| M20 | hsa04115 : p53 signaling pathway | 3.3E–10 |
| hsa04110 : cell cycle | 2.5E–8 | |
| hsa04914 : progesterone-mediated oocyte maturation | 1.8E–3 | |
| M22 | hsa04810 : regulation of actin cytoskeleton | 1.6E–2 |
| hsa04666 : Fc gamma R-mediated phagocytosis | 2.4E–2 | |
| hsa04530 : tight junction | 4.4E–2 | |
| M23 | hsa04144 : endocytosis | 1.5E–2 |
| hsa04540 : gap junction | 2.7E–2 | |
| M25 | hsa04510 : focal adhesion | 2.7E–2 |
| hsa04512 : ECM-receptor interaction | 3.1E–2 |