Table 4. Clique analysis.
The list of complexes enriched for CSF and PBMCs.
| Gene symbol | Complex |
|---|---|
| CSF (MS vs. controls) | |
| PSMA3, PSMB1, PSMB3, PSMB9, PSME1, PSMD7 | Proteasome (ID:39, 192,193) |
| GPS2, NCOR2, TBL1X | SMRT complex (ID:58) |
| EED, EZH2, RBBP4 | Polycomb repressive complex 2,3 (PRC 2,3) (ID:105, 996,995), EED-EZH2 complex (ID:974) |
| CCNB1, CCNB2, CCND1, CDK1, CDKN1A | Cell cycle kinase complex CDC2 (ID:310) |
| CCND1,CCND3, CDKN1A | Cell cycle kinase complex CDK5 (ID:313) |
| CBX5, DSN1, ZWINT | Mis12 centromere complex (ID:1464) |
| CTNNA1, CTNNB1, SDCBP | SDCBP-CTNNB1-CTNNA1-CDH1 complex (ID:1839) |
| TUBA1A, TUBA1B, TUBA1C | 60S APC containing complex (ID:3008) |
| IGF2BP1, ILF2, NOLC1, RPLP2, RPS11, RPS16, SRPK1, TUBA1A, YBX1 | Nop56p-associated pre-rRNA complex (ID:3055) |
| MAP2K1, SFN, YWHAG | Ksr1 complex (Ksr1, Mek, 14-3-3, Mapk), EGF stimulated (ID:5909, 5886) |
| PBMCs (relapse vs. remission) | |
| PSMA1, PSMA2, PSMA7, PSMB10, PSMB3, PSMD3, PSMD4 | Proteasome (ID: 38, 39, 181, 191, 192, 193, 194) |
| DHX15, PABPC1, PRPF19, SF3B3, SNRPB | Spliceosome (ID:351) |
| ACTB, ANXA6, MYH9, SPTAN1 | PA700-20S-PA28 complex (ID:437) |
| HNRNPH1, HNRNPM, PABPC1, PRPF19, SF3B3, SNRPB | C complex spliceosome (ID:1181) |
| CDC37, HSP90AB1, MAP3K3 | Kinase maturation complex 1 (ID:5199) |
| CDC37, HSP90AB1, IKBKE | TNF-alpha/NF-kappa B signaling complex 8 (ID: 5269) |
| CASP8 FADD FAS | FAS-FADD-CASP8 complex (ID: 5473, 5860), FAS-FADD-CASP8-CASP10 complex (ID: 5859), Death induced signaling complex DISC (ID: 5799, 5800) |
| ACTB, MYH9, SPTAN1 | Emerin complex 1 (ID: 5604) |