Figure 1.

Differences in ADC values during DKA compared with post-recovery (percent changes). The line in the middle of each box indicates the median (50% percentile), the top and bottom indicate the 75^th / 25^th percentiles, and the diamond indicates the mean. The whiskers extend toward the maximum and minimum values to a maximum length of 1.5 interquartile ranges. Individual values beyond the whiskers are possible outliers. For imputed values, the depicted value is based on the geometric mean treatment to recovery ratio across the 100 multiple imputation datasets (n=45 for occipital cortex and thalamus, n=43 for frontal cortex and basal ganglia, n=18 for hippocampus, n=16 for medulla).

Region-specific geometric mean (95% CI) treatment to recovery ratios (GMR) and between-region relative geometric mean ratios (RGMR)

	GMR (95% CI)	RGMR (95% CI), Relative to Occipital Cortex	RGMR (95% CI), Relative to Medulla
Frontal cortex	1.05 (1.03, 1.07)	1.05 (1.01, 1.09)	1.08 (1.02, 1.15)
Basal ganglia	1.07 (1.04, 1.09)	1.07 (1.03, 1.11)	1.09 (1.01, 1.17)
Hippocampus	1.04 (1.01, 1.07)	0.99 (0.95, 1.03)	1.06 (1.001, 1.13)
Thalamus	1.05 (1.02, 1.07)	1.05 (1.01, 1.08)	1.06 (0.98, 1.14)
Occipital cortex	1.00 (0.97, 1.03)	Reference	1.07 (1.01, 1.15)
Medulla	0.98 (0.93, 1.03)	0.93 (0.87, 0.99)	Reference

Pooled estimates from 100 multiple imputation datasets. Boldface indicates estimate is statistically significantly different from 1 (p<0.05).