(A,B) Tb response to AMP (100 mg/kg, i.p.) in C57BL/6J (WT) and Adora1−/− (KO) mice (n=6/group). (C,D) Tb response to AMP (100 mg/kg, i.p.) in C57BL/6J (WT) or Adora3−/− mice (n=4/group). (E,F) Tb response to AMP (100 mg/kg, i.p.) in C57BL/6J and Adora1−/−;Adora3−/− mice (n=5–6/group). (G,H) Tb response to AMP (100 mg/kg, i.p.) in C57BL/6J (WT) or KitW-sh/Wsh mice (n=7–8/group). Data are mean ± SEM; every tenth SEM is shown in A, C, E, and G; * p<0.05, ** p<0.01, *** p<0.001.