Table 3.
Effects of [Dmt1]N/OFQ(1-13)-NH2 and PWT2-[Dmt1] at NOP and classical opioid receptors coupled with calcium signaling via chimeric G proteins.
| NOP | mu | kappa | delta | |||||
|---|---|---|---|---|---|---|---|---|
| pEC50
(CL95%) |
α± S.E.M. |
pEC50
(CL95%) |
α± S.E.M. |
pEC50
(CL95%) |
α± S.E.M. |
pEC50
(CL95%) |
α± S.E.M. |
|
|
[Dmt1]N/OFQ(1-
13)-NH2 |
9.18 (8.71- 9.64) |
0.99 ± 0.04 |
7.78 (7.14- 8.42) |
0.85 ± 0.04 |
7.66 (7.37- 7.95) |
0.92 ± 0.03 |
7.24 (6.92- 7.57) |
0.83 ± 0.07 |
| PWT2-[Dmt1] | 7.83 (7.62- 8.03) |
0.98 ± 0.08 |
6.82 (6.20- 7.43) |
0.87 ± 0.04 |
6.40 (6.20- 6.60) |
0.86 ± 0.03 |
6.79 (6.42- 7.16) |
0.80 ± 0.08 |
N/OFQ, dermorphin, dynorphin A and DPDPE were used as standard agonists for calculating intrinsic activity at NOP, mu, kappa, and delta receptor respectively.