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Organization of the nystatin P1 biosynthesis gene cluster in Ae707_Ps1 and model for its biosynthesis deduced from the PKS assembly line. ACP, acyl carrier protein; AT, acyl transferase; DH, dehydratase; ER, enoylreductase; KR, ketoreductase, KS, ketosynthase; KSS, nys-like loading KS; TE, thioesterase. ∗Domains labeled with an asterisk indicate inactive domains. Parts of the proposed structures which are pictured in gray are due to post-PKS tailoring steps.
