Table 1.

Summary of related TGR5 information.

Gene	GPBAR1, 2q35
Expression in human tissues	Placenta, Spleen, Small intestine, Stomach, Liver, Lung, Heart, Skeletal muscle, Kidney, Peripheral blood leukocytes
Natural agonists		Name	Structures	References
	Primary bile acid	CA		Kawamata et al., 2003
		CDCA		Kawamata et al., 2003
	Secondary bile acid	LCA		Kawamata et al., 2003
		TLCA		Kawamata et al., 2003
		DCA		Kawamata et al., 2003
Natural phytochemical agonists		Linolenic acid		Katsuma et al., 2005
		OA		Sato et al., 2007
		Obacunone		Horiba et al., 2015
Synthetic agonists	INT-777			Pellicciari et al., 2009
	TRC210258			Zambad et al., 2013
	WB403			Zheng et al., 2015
Relevant diseases			Agonists	References
	Type 2 diabetes		LCA, DCA, Lionlenic acid, OA, INT-777, WB403	Katsuma et al., 2005; Sato et al., 2007; Perino et al., 2014; Zheng et al., 2015
	Obesity		CA, TCA, DCA, CDCA	Watanabe et al., 2006
	Inflammation		Betulinic acid, 23(S)-mCDCA, TLCA, TLC, CDCA, DCA	Kawamata et al., 2003; Keitel et al., 2008; Wang et al., 2011; Mobraten et al., 2015; Guo et al., 2015b; McMillin et al., 2015
	Gastric cancer		23(S)-mCDCA, GPBARA	Guo et al., 2015a
	Liver regeneration		CA	Péan et al., 2013