Figure 2.

PFS suppressed the expression of inflammatory cytokines. AIA was induced as detailed in Methods. Arthritic rats were treated with 50 mg/kg PFS for 35 days. Day 28: splenocytes were harvested for measuring cytokine expression by quantitative RT-PCR. (a) RT-PCR analysis of inflammatory cytokine genes and related transcription factors and (b) relative amounts of each cytokine gene level were determined by densitometric analysis. Dunnett's test. N: normal; C: control; M: marker. ns: no significant difference.