Table 1.
Frequency of interleukin-1α, -2, -8, -10, -13, TNF-α and endothelin-1 gene polymorphisms in CTCL patients and healthy controls
| Variables | CTCL patients | Controls | P-value –χ2 Pearson test |
|---|---|---|---|
| rs1800587 (–889 C/T) polymorphism in the promoter region of the interleukin-1α gene | |||
| Genotypes: CC CT TT |
n = 42 26(61.90%) 14 (33.3%) 2 (4.8.0%) |
n = 99 51 (51.5%) 45 (45.5%) 3 (3.0%) |
0.26 0.18 0.61 |
| Alleles: C T |
n = 84 66 (78.5%) 18 (21.5%) |
n = 198 147 (74.2%) 51 (25.8%) |
0.44 |
| rs2069762 (–330 G/T) polymorphism in the promoter region and rs2069763 (+166G/T) in exon 1 of the interleukin-2 gene | |||
|
rs2069762 (–330G/T) Genotypes: GG GT TT rs2069763 (+166G/T) Genotypes: GG GT TT |
n = 42 11(26.2%) 8 (19.0%) 23 (54.8%) 29 (69.1%) 11 (26.2%) 2 (4.7%) |
n = 87 5 (5.8%) 48 (55.2%) 34 (39.0%) 41 (47.1%) 41 (47.1%) 5 (5.8%) |
0.001 (OR = 5.82, 95% CI: 1.87–18.11, p = 0.0024) 0.0001 (OR = 0.19, 95% CI: 0.08–0.46, p = 0.0002) 0.09 0.0192 (OR = 2.50, 95% CI: 1.15–5.45, p = 0.02) 0.0231 (OR = 0.40, 95% CI: 0.18–0.89, p = 0.02) 0.82 |
| Alleles: –330 G –330 T +166 G +166 T |
n = 84 54 (64.3%) 30 (35.7%) 69 (82.1%) 15 (17.9%) |
n = 174 58 (33.3%) 116 (66.7%) 123 (70.7%) 51 (29.3%) |
< 0.00001 (OR = 3.60, 95% CI: 2.08–6.22, p < 0.0001) 0.0482 (OR = 1.9, 95% CI: 0.99–3.64, p = 0.05) |
| rs4073 (–251 A/T) polymorphism in the promoter region of the interleukin-8 gene | |||
| Genotypes: AA AT TT |
n = 42 6 (14.3%) 21 (50.0%) 15 (35.7%) |
n = 175 42 (24.0%) 94 (53.7%) 39 (22.3%) |
0.17 0.66 0.07 |
| Alleles: A T |
n = 84 33 (39.3%) 51 (60.7%) |
n = 350 178 (51.8%) 172 (49.1%) |
0.06 |
| rs1800896 (–1082 A/G) polymorphism in the promoter region of the interleukin-10 gene | |||
| Genotypes: GG GA AA |
n = 43 5 (11.6%) 30 (69.8%) 8 (18.6%) |
n = 173 47 (27.2%) 90 (52.0%) 36 (27.2%) |
0.0329 (OR = 0.35, 95% CI: 0.13–0.95, p = 0.04) 0.0361 (OR = 2.13, 95% CI: 1.04–4.35, p = 0.04) 0.75 |
| Alleles: A G |
n = 86 40 (46.5%) 46 (53.5%) |
n = 346 162 (46.8%) 184 (53.2%) |
0.96 |
| rs1800629 (–308 G/A) promoter polymorphism of the TNF-α gene | |||
| Genotypes: GG GA AA |
n = 43 36 (83.7%) 7 (16.3%)0 |
n = 261 178 (68.2%) 80 (30.6%) 3 (1.1%) |
0.0388 (OR = 2.4, 95% CI: 1.02–5.61, p = 0.04) 0.05 0.50 |
| Alleles: A G |
n = 86 7(8.0%) 79 (92.0%) |
n = 522 86 (16.5%) 436 (83.5%) |
0.0466 (OR = 0.45, 95% CI: 0.20–1.00, p = 0.05) |
| rs1800925 (–1112 C/T) polymorphism in the promoter region of the interleukin-13 gene | |||
| Genotypes: CC CT TT |
n = 42 18 (42.9%) 18 (42.9%) 6 (14.2%) |
n = 175 71 (40.6%) 99 (56.6%) 5 (2.8%) |
0.79 0.11 0.0024 (OR = 5.67, 95% CI: 1.64–19.58, p = 0.006) |
| Alleles: C T |
n = 84 54 (64.3%) 30 (35.7%) |
n = 350 241 (68.9%) 109 (31.1%) |
0.42 |
| rs5370 (K198N) polymorphism of the endothelin-1 gene | |||
| Genotypes: GG GT TT |
n = 60 39 (65%) 21 (35%) 0 |
n = 107 69 (64.5%) 35 (32.7%) 3 (2.8%) |
0.95 0.76 0.19 |
| Alleles: G T |
n = 120 99 (82.5%) 21 (17.5%) |
n = 214 173 (80.8%) 41 (19.2%) |
0.71 |
| rs1800541 (–1370T/G) polymorphism in the promoter region of the endothelin-1 gene | |||
| Genotypes: TT TG GG |
n = 60 29 (48.3%) 28 (46.7%) 3 (5%) |
n = 107 41 (38.3%) 61 (57.0%) 5 (4.7%) |
0.21 0.20 0.92 |
| Alleles: T G |
n = 120 86 (71.7%) 34 (28.3%) |
n = 214 143 (66.8%) 71 (33.2%) |
0.36 |