Fig. 5.

ETC complex activity increases with exercise training independent of PGC-1 expression. A: NADH dehydrogenase (Complex I) activity. B: succinate dehydrogenase/cytochrome-c reductase (Complex II-III) activity. C: cytochrome-c reductase (Complex III) activity. D: cytochrome-c oxidase (Complex IV) activity. E: ATP synthase (Complex V) activity from gastrocnemius (GAS) muscle of iMyo-PGC-1DKO and control littermates, exercised and sedentary. F: percentage change from sedentary controls. Data are presented as means ± SE; n = 4–5 per group; *P < 0.05 compared with sedentary control; #P < 0.05 compared with sedentary iMyo-PGC-1DKO animals. P values were determined by 2-way ANOVA with pairwise comparisons (Tukey adjustment) for A–E.