Figure 4.

Hierarchy of tissue cell differentiation by an involvement of distinct elements of the tissue control system. A: The differentiation of tissue cells may pass up to nine stages (s1-s9). The epithelial cells pass through basal to parabasal b/pb, from parabasal to intermediate pb/im and from intermediate to superficial im/s layers, with intermediate steps in between; B: Cellular differentiation is regulated by distinct IMS components. The stem cell asymmetric division is mediated by primitive MDC (PM) and T cell (T). The pericytes (PC) cause s2 > s3 transition by substances released from Thy-1 intercellular vesicles. DR⁺ dendritic cell precursors (DCP) stimulate s3 to s4 transfer, s4 > s5 stage is caused by a binding of IgM¹, and regression of intraepithelial T lymphocytes (IEL) induces s5 > s6 transition. Regressing dendritic cells (DC) cause s6 > s7 change, binding of IgM² induces s7 > s8 transfer, and binding of IgG accompanies s8 > s9 stage exhibiting a binding of IgM³. > X indicates the regression IEL and DC[1].