Table 1.
Baseline demographics and clinical characteristics n (%)
| Characteristics | Risperidone (n = 43) | Olanzapine (n = 42) | Quetiapine (n = 42) | Ziprasidone (n = 46) | All patients (n =173) |
| Gender | |||||
| Male | 34 (79.1) | 28 (66.7) | 29 (69.0) | 29 (63.0) | 120 (69.4) |
| Antipsychotic naïve | 17 (40.5) | 15 (35.7) | 21 (50.0) | 20 (44.4) | 73 (42.7) |
| Alcohol last 6 mo | |||||
| None/no misuse | 10 (23.3) | 7 (16.7) | 7 (16.7) | 10 (21.7) | 34 19.7) |
| Dependency | 2 (4.7) | 4 (9.5) | 6 (14.3) | 0 (0.0) | 12 (6.9) |
| Drugs last 6 mo | |||||
| None | 26 (60.5) | 31 (73.8) | 30 (71.4) | 32 (69.6) | 119 (68.8) |
| Misuse | 10 (23.3) | 6 (14.3) | 7 (16.7) | 7 (15.2) | 30 (17.3) |
| Diagnosis1 | n (39) | n (42) | n (41) | n (44) | n (166) |
| Schz and rel. | 22 (56.4) | 25 (59.5) | 25 (61.0) | 22 (50.0) | 94 (56.6) |
| Acute | 4 (10.3) | 4 (9.5) | 2 (4.9) | 4 (9.1) | 14 (8.4) |
| Drug-induced | 6 (15.4) | 6 (14.3) | 5 (12.2) | 5 (11.4) | 22 (13.3) |
| Affective | 4 10.3) | 4 (9.5) | 6 (14.6) | 5 (11.4) | 19 (11.4) |
| Rest | 3 (7.7) | 3 (7.1) | 3 (7.3) | 8 (18.2) | 17 (10.2) |
| Age mean (SD) | 34.5 (15.6) | 32.3 (11.2) | 37.2 (14.8) | 32.4 (13.5) | 34.1 (13.9) |
| QTc admittance mean (SD) | 422.1 (39.7) | 420.9 (33.5) | 421.1 (25.1) | 420.4 (22.0) | 421.1 (30.4) |
| PANSS total mean (SD) | 73.4 (14.0) | 76.0 (14.3) | 73.6 (14.0) | 70.8 (12.4) | 73.4 (13.7) |
| PANSS positive mean (SD) | 18.6 (4.9) | 21.3 (4.6) | 20.0 (3.6) | 18.8 (3.9) | 19.7 (7.5) |
| PANSS negative mean (SD) | 20.8 (8.1) | 18.3 (7.3) | 19.2 (7.1) | 18.4 (7.4) | 19.2 (7.5) |
| PANSS general mean (SD) | 34.0 (6.5) | 36.4 (6.6) | 34.4 (7.6) | 33.6 (6.3) | 34.6 (6.8) |
| CDSS mean (SD) | 6.8 (4.9) | 6.3 (4.9) | 6.4 (4.9) | 7.8 (6.4) | 6.9 (5.3) |
| GAF-F mean (SD) | 30.8 (5.9) | 30.1 (6.0) | 30.6 (7.2) | 32.2 (5.0) | 30.9 (6.0) |
| CGI mean (SD) | 5.2 (0.6) | 5.3 (0.7) | 5.1 (0.7) | 5.0 (0.6) | 5.2 (0.6) |
Patients with missing diagnoses are not included in the list. n: Number of patients with ECG at baseline and or ECG at discharge; SD: Standard deviation; Antipsychotic naïve: No life-time exposure to antipsychotic drugs before index admission; First admission: Index admission was the first admission to a mental hospital; Misuse: Misuse or Dependence according to Drake et al[13]; Schz and rel.: Schizophrenia and related disorders: Schizophrenia, schizo-affective disorder, acute polymorphic psychotic disorder with symptoms of schizophrenia, acute schizophrenia-like psychotic disorder, delusional disorder; Acute: Acute psychosis other than those categorized under Schz and rel.; Affective: Affective psychosis; Rest: Miscellaneous psychotic disorders; All diagnoses are according to ICD-10; PANSS: The Positive and Negative Syndrome Scale; CDSS: The Calgary Depression Scale for Schizophrenia; GAF-F: The Global Assessment of Functioning, split version, Functions scale; CGI: The Clinical Global Impression, severity of illness scale.