Table 1.
Single and combinations of medications utilized to treat combat nightmares.
| Medications | Number of Trials | No Responses | Partial Response | Full Response | Total Success |
| Alpha 2 Adrenergic Receptor Agonists | |||||
| Prazosin (Aurora 2010 ber/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
106 | 54 (51%) −20.0 (1–2005) |
46 (43%) −10.00 (7–2222) |
6 (6%) −10.0 (12–2003) |
49% |
| Clonidine (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
27 | 10 (37%) −4.0 (2–1087) |
17 (63%) 0.1–2.0 (21–1216) |
0 | 63% |
| Terazosin (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
26 | 10 (39%) 1.0–20.0 (8–1995) 551 |
16 (61%) −50.0 (21–2190) |
0 | 61% |
| Atypical Antipsychotics/Benzisoxazole derivatives | |||||
| Risperidone (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
81 | 19 (23%) 0.25–5.0 (3–1580) |
41 (51%) 0.5–6.0 (6–2175) |
21 (26%) 0.5–3.0 (5–2615) |
77% |
| Quetiapine (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
72 | 36 (50%) 12.5–500.0 (1–2527) |
30 (42%) 25.0–800.0 (2–2520) |
6 (8%) 12.5–50.0 (6–287) |
50% |
| Olanzapine (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
5 | 0 | 4 (80%) 2.5–10.0 (78–1170) 410 |
(20%) 5.0 105 |
100% |
| Aripiprazole (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
4 | (75%) 5.0–10.0 (7–2100) |
1 (25%) 10.0 1095 |
0 | 25% |
| Ziprasidone (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
3 | 1 (33.3%) 40 90 |
2 (67%) 40.0–80.0 (365–486) |
0 | 67% |
| Typical Antipsychotics | |||||
| Perphenazine (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
4 | 1 (25%) 2.0 120 |
2 (50%) −8.0 (325–485) |
1 (25%) 8.0 257 |
75% |
| Antidepressants | |||||
| Trazodone (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
22 | 14 (64%) 50.0–200.0 (2–4375) |
7 (32%) 50.0–300.0 (231–1395) |
1 (4%) 200.0 295 |
36% |
| Mirtazapine (number/percent) Dose range (mg) Maximum Treatment range (days)(avg) |
20 | 10 (50%) 7.7–30.0 (10–1326) |
9 (45%) 7.5–30.0 (48–5630) |
1 (5%) 15.0 5 |
50% |
| Medication Combinations Utilized to Treat Combat Nightmares | |||||
| Medications | Number | No Responses Number of Responses, Dose Range, Length of Treatment (Days) | Partial Response Number of Responses, Dose Range, Length of Treatment (Days) | Full Response Number of Responses, Dose Range, Length of Treatment (Days) | Total Success |
| prazosin + trazodone (number/percent) Dose range (mg) Maximum Treatment range (days) |
5 | 3 (60%) 2.0–10.0 + 50–100 (2–1152) |
2 (40%) 2.0–4.0 + 50–200 (169–750) |
0 | 40% |
| prazosin + quetiapine (number/percent) Dose range (mg) Maximum Treatment range (days) |
5 | 4 (80%) 1.0–5.0 + 25–450 (13–364) |
1 (20%) 2.0–25 187 |
0 | 20% |