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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Oct 6;26(22):5573–5579. doi: 10.1016/j.bmcl.2016.09.072

Table 2.

JWS analogs with different aromatic groups and their multiple activities

graphic file with name nihms824135t2.jpg
Compound R AChE (IC50 µM) BuChE (IC50 µM) M1(%)a M2(%) M3(%) M4(%)
14 graphic file with name nihms824135t3.jpg 16.18 7.65 56.2 50.8 24.3 24.9
15 graphic file with name nihms824135t4.jpg 5.34 8.36 n.t. n.t. n.t. n.t.
16 graphic file with name nihms824135t5.jpg 10.41 >50 25.2 9.8 2.3 7.7
17 graphic file with name nihms824135t6.jpg >50 >50 69.9 72.8 49.8 42.7
18 graphic file with name nihms824135t7.jpg >50 >50 57.4 71.3 30.1 43.6
19 graphic file with name nihms824135t8.jpg 4.04 21.18 72.1 54 41.5 47.7
20 graphic file with name nihms824135t9.jpg 1.18 2.96 88.5 67 66.6 62.3
21 graphic file with name nihms824135t10.jpg 1.65 7.1 88.8 81 90.4 92.1
22 graphic file with name nihms824135t11.jpg >50 >50 37.5 −19 18.5 4.2
23 graphic file with name nihms824135t12.jpg >50 47.21 n.t. n.t. n.t. n.t.
24 graphic file with name nihms824135t13.jpg >50 >50 n.t. n.t. n.t. n.t.
25 graphic file with name nihms824135t14.jpg >50 >50 77.4 50.8 69.6 33.8
26 graphic file with name nihms824135t15.jpg 5.01 7.65 60.1 27.4 43.5 47.3
a

Muscarinic receptor activities are the percentage of binding inhibition.