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. Author manuscript; available in PMC: 2016 Dec 26.
Published in final edited form as: J Control Release. 2016 Aug 5;238:272–280. doi: 10.1016/j.jconrel.2016.08.005

Fig. 5.

Fig. 5

Quantitative RT-PCR assessment of non-resistant human HCC xenografts in mice intravenously injected with either control PLGA-NP (no miRNA loading) or with miRNA-loaded PLGA-NP that were either treated or not treated with ultrasound (US). (A) shows fold increase of respective miRNA levels at 4 h, (B) shows them at 24 h following treatment. *, P = 0.005, **, P = 0.002; ***, P = 0.001, all compared to untreated control tumors; n = 5 each. Representative TEM image shows internalization of PLGA-NP (red arrows) into a HCC cell (C) through endocytosis. (D) PLGA-NP (red arrow) is shown within a vesicular structure (yellow arrow) in a HCC cell by TEM. (E) Degrading PLGA-NP (red arrow) aggregates in the cytoplasm of a HCC cell (red arrow).