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. Author manuscript; available in PMC: 2017 Jun 8.
Published in final edited form as: Cell Host Microbe. 2016 May 19;19(6):849–864. doi: 10.1016/j.chom.2016.05.001

Figure 2. Qsp1 Is Required for Virulence and Accumulation within Macrophages.

Figure 2

(A) Survival analysis. 10 A/J mice infected per genotype. **p < 10−4 (log-rank test).

(B) Lung burden analysis. 9 A/J mice infected per genotype. **p < 10−3, ***p < 10−4 (t test).

(C) Leukocyte recruitment. 4 C57Bl/6 mice infected with wild-type, 8 C57Bl/6 mice infected per qsp1Δ strain.

(D) Cytokine analysis. 10 C57Bl/6 mice infected per genotype. Error bars are SD.

(E and F) Phagocytic index of unopsonized (E) and opsonized (F) C. neoformans. >1,200 BMDMs quantified per genotype. Error bars are SD.

(G) Intracellular accumulation. CFUs from BMDM cell lysates, normalized to starting inoculum. Error bars represent 95% confidence intervals constructed by bootstrapping. *p < 0.05 (bootstrap).