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. 2004 Oct 1;114(7):969–978. doi: 10.1172/JCI22103

Figure 5.

Figure 5

NOD mice reconstituted with either MMP-IAβ-d-GFP_ or MMP-IAβ-k-GFP_transduced bone marrow are protected from diabetes. (A) NOD mice were reconstituted with bone marrow retrovirally transduced with MMP-IAβ-d-GFP (open circles, n = 6), MMP-IAβ-k-GFP (×, n = 6), or control MMP-GFP (filled squares, n = 6). Shown are the percentages of normoglycemic mice at each time point after bone marrow transplantation. (B) NOD mice reconstituted with bone marrow retrovirally transduced with either MMP-IAβ-d-GFP or MMP-IAβ-k-GFP are protected from cyclophosphamide-induced diabetes. NOD mice were reconstituted with bone marrow transduced with MMP-IAβ-d-GFP (open circles, n = 12), MMP-IAβ-k-GFP (×, n = 12), or control MMP-GFP (filled squares, n = 14). Twenty-one weeks after bone marrow transplantation, mice were injected intraperitoneally with 200 mg/kg cyclophosphamide. Shown are the percentages of normoglycemic mice at each time point after bone marrow transplantation. Data in A and B are the combined results of 2 independent experiments. In all experiments, blood glucose levels were measured weekly.