Table 2.
Genotype distribution and allele carriage rates of two single-nucleotide polymorphisms (SNPs) in the gene encoding IL-7Rα in patients with and without thymic hyperplasia (TH) following chemotherapy.
| SNP locus | Genotype/allele | Patients with TH (n = 38) | Patients without TH (n = 96) | Odds ratios [95% confidence intervals] | P-value |
|---|---|---|---|---|---|
| rs7718919 | GG GT TT |
24 (0.632) 12 (0.316) 2 (0.053) |
78 (0.812) 15 (0.156) 3 (0.031) |
0.084 | |
| TT GG + GT |
2 (0.053) 36 (0.947) |
3 (0.031) 93 (0.969) |
1.722 [0.276–10.737] | 0.622 | |
| GT + TT GG |
14 (0.368) 24 (0.632) |
18 (0.187) 78 (0.813) |
2.528 [1.097–5.826] | 0.027 | |
| T G |
16 (0.211) 60 (0.789) |
21 (0.109) 171 (0.891) |
2.171 [1.064–4.433] | 0.031 | |
| rs6897932 | CC CT TT |
27 (0.711) 11 (0.289) 0 (0.000) |
59 (0.615) 34 (0.354) 3 (0.031) |
0.383 | |
| CC + CT TT |
38 (1.000) 0 (0.000) |
93 (0.969) 3 (0.031) |
1.413 [1.265–1.578] | 0.577 | |
| CC CT + TT |
27 (0.711) 11 (0.289) |
59 (0.615) 37 (0.385) |
1.539 [0.683–3.469] | 0.325 | |
| C T |
65 (0.855) 11 (0.145) |
152 (0.792) 40 (0.208) |
1.555 [0.751–3.220] | 0.282 |