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Stress levels after 21 days of restraint stress paradigm. (A) Chronic stress decreased body weight gain, while reboxetine prevented this effect. (B) After acute swim, serum corticosterone levels were significantly higher in chronically stressed rats treated with vehicle than in control animals (black bars), while reboxetine prevented this effect (black bars). (C) Reboxetine did not affect the locomotor activity of animals in the experimental groups. **p < 0.01, ***p < 0.001.
