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Tissue oxygenation responses (TOI) in COR (•) and PLA (o) as % change from rest (60 min) to each steady state (SS) (A) and Sprint (Spr) (B) interval. Main effect of drug (a) and time (b). Significant differences in COR from 60 to Spr 1 (**P < 0.01). Trend for COR Spr 4 and 5 (#P = 0.06 and 0.07 respectfully) to be lower than COR 60. COR significantly lower than PLA 60 at Spr 1, 4, and 5 (&P < 0.05). Significant difference between COR and PLA at Spr 5 (δP < 0.05).
