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. 2016 Dec 27;7:170. doi: 10.3389/fendo.2016.00170

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Copyright © 2016 Tsutsui and Ubuka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gonadotropin-inhibitory hormone (GnIH) control of feeding behavior. GnIH also participates in the control of feeding behavior in birds and mammals. Central administration of GnIH increases food intake in birds and mammals. GnIH neurons project to neuropeptide Y (NPY) neurons and pro-opiomelanocortin (POMC) neurons. GnIH inhibits the firing rate in POMC neurons and has a predominantly inhibitory effect on action potential activity in NPY neurons. Thus, GnIH neurons may stimulate feeding behavior by inhibiting POMC neurons and NPY neurons in the hypothalamus. Future studies are needed to further develop the concept of central mechanism of GnIH actions on the control of feeding behavior. See the text for details.