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. 2016 Dec 27;4:149. doi: 10.3389/fcell.2016.00149

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Copyright © 2016 Matsubara, Nakano, Kawamura, Tsudzuki, Funahashi, Agata, Matsuda, Kuroiwa and Suzuki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of Fgf8 at the apical ectodermal ridge (AER) is expanded along the anterior-posterior (AP) axis in the hmm^−/− limb bud. (A,B) Morphology of the limb at St. 22 as scanned by OPT. Dorsal view (A) and lateral view (B) of the hmm^+/− (green) and hmm^−/− (yellow) hindlimb buds. The scale bar indicates 1 mm. (C–F) In situ hybridization of MyoD. The dotted line shows the anterior and posterior end of the limb buds. Numbers indicate the position of the somite starting with the first somite. (G–N) In situ hybridization of Fgf8. Yellow arrowheads indicates the boundary between the limb bud and the body wall. Red arrowheads indicate the anterior and posterior boundaries of Fgf8 expression at the AER. A, anterior; P, posterior; D, dorsal; V, ventral; FLB, forelimb bud; HLB, hindlimb bud.