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. 2016 Dec 27;2:16051. doi: 10.1038/celldisc.2016.51

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Dimerization of CASTOR1 might have a critical role in relieving the inhibition of GATOR1 by GATOR2. (a) In the structure of CASTOR1 dimer, the GATOR2-binding sites (residues Y118/Q119/D121, marked by red circles) on the two CASTOR1 protomers are located on the same side and face the same direction. (b) A schematic model showing that the dimerization of CASTOR1 leads to juxtaposition of two GATOR2 complexes on the relatively small CASTOR1 dimer, which creates spatial hindrance for their bound GATOR1 complexes. GATOR1 is thus dissociated from GATOR2 and relieved from its inhibition.