Figure 3. Estimated and measured kinetic parameters.

Comparison of the computed (a) Michaelis constant K_m and (b) turnover number k_cat in k-ecoli457 and the values reported in BRENDA²⁴ and EcoCyc²⁵. The error bars denote 1 s.d. confidence interval for the corresponding parameter, the dots represent the mean value of the measured versus computed parameters and dashed lines show equal predicted and measured parameters. Comparison of the computed (c) K_m and (d) k_cat in k-ecoli457 (left) and the core model (right)¹⁵. The numbers within the circle plots indicate the number of measured parameters and the darker sectors represent the portion of the parameters whose estimated ranges overlap experimentally reported ranges.