Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 29;6(4):57. doi: 10.3390/brainsci6040057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Dopamine-dependent dynamics of subthalamic nucleus (STN) local field potential (LFP) activity recorded with an implantable neurostimulator (INS) with behavioral events. Subjects performed (A) left and right button press, Time 0 ms indicates digital response; (B) left and right reach, Time 0 ms indicates detection of reaching target by a touch-screen monitor; (C) tongue extension, Time 0 ms indicates first observance of tongue with a time-synced video recording; and speech, Time 0 ms indicates the onset of speech as detected by a time synced audio recording. Medication on recordings were performed at three months post DBS lead implant. Medication off recordings were performed at six months post DBS lead implant. STN-LFP event-related desynchronization (ERD) in beta (13–30 Hz) frequencies was observed in the medication off state. STN-LFP ERD in beta frequencies and event-related synchronization in low gamma (35–70 Hz) frequencies were observed in the medication on state. One bipolar channel pair was selected from each hemisphere for behavioral recordings (listed in Table 1). Figure S3 provides the spectrograms for all subjects performing each behavior.