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. 2016 Dec 21;7:13916. doi: 10.1038/ncomms13916

Figure 8. Histopathology following RSV challenge in cotton rats.

Figure 8

To evaluate for vaccine attributable enhanced disease post challenge, groups of five cotton rats were inoculated intramuscularly with FI-RSV or intranasally with either mock or OE4. Animals vaccinated with FI-RSV also received a boost on day 21 p.i. All animals were challenged with A2-line19F on day 42 p.i., lungs were harvested 4 days later and histopathology scores were performed (a). Representative haematoxylin and eosin stains for FI-RSV (b), mock (c) and OE4 (d) vaccinated rats are shown. Scale bars represent 200 μm. Data are represented as mean+s.d. *P<0.05, **P<0.005 by two-way ANOVA.