Fig. 2.

Functional classification of genes missing or inactivated in Y. pestis. Distribution of Y. pestis-specific lost functions by gene region deletion (light blue) or by gene inactivation (i.e., pseudogene, dark purple) in COG functional groups: C, energy production; D, cell division and/or chromosome partitioning; E, amino acid metabolism; F, nucleotide metabolism; G, carbohydrate metabolism; H, coenzyme metabolism; I, lipid metabolism; J, translation; K, transcription; L, DNA replication and/or repair; M, cell envelope biogenesis; N, cell motility, secretion; O, posttranslational modification; P, inorganic ion metabolism; R, general function prediction only; S, function unknown; T, signal transduction; conserved, conserved hypothetical genes with no significant COG hits; and unique, hypothetical genes with no significant COG hit.