Table S1.
Reductive flux to citrate in different cell lines and tissues
| Cell line/tissue | Total CIT, μmol/μg protein | % CIT with 13C label (M1–M6) | Reductive path, % M5 CIT | Oxidative path, % M4 CIT |
| hfRPE | 17.5 ± 0.5 | 37.5 ± 5.3 | 17.7 ± 1.5 | 8.1 ± 1.4 |
| iPSC RPE | 27.2 ± 2.6 | 47.3 ± 4.5 | 25.7 ± 1.2 | 10.0 ± 1.1 |
| ARPE-19 | 20.0 ± 2.8 | 20.9 ± 0.0 | 9.9 ± 0.7 | 8.1 ± 0.6 |
| Müller glia | 20.0 ± 3.3 | 55.0 ± 0.9 | 5.1 ± 0.2 | 30.4 ± 0.9 |
| hCardiac EC | 12.3 ± 2.5 | 17.9 ± 0.8 | 4.5 ± 0.3 | 11.2 ± 0.3 |
| HeLa | 26.7 ± 0.6 | 65.4 ± 0.9 | 4.2 ± 0.4 | 45.2 ± 0.2 |
| Retina | 6.9 ± 0.9 | 27.6 ± 0.8 | 2.7 ± 0.2 | 17.1 ± 1.0 |
| Cerebellum | 7.6 ± 1.0 | 18.9 ± 0.6 | 0.3 ± 0.1 | 11.3 ± 0.7 |
| Hippocampus | 7.6 ± 0.8 | 29.0 ± 1.4 | 0.9 ± 0.3 | 20.5 ± 1.2 |
| Olfactory bulb | 5.1 ± 0.6 | 15.5 ± 2.1 | 0.5 ± 0.0 | 9.7 ± 1.4 |
CIT, citrate.