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Shape of the tunnel site in PrfAWT (PDB ID code 2BEO) (A) and PrfAWT with bound GSH (B). The cofactor and protein atoms are color-coded as in Fig. 1E. The figure highlights the effects of the major conformational changes that occur at the tunnel site following binding of GSH. The conformational changes diminish the size of the tunnel, particularly at the glycine end of the ligand, leading to stable formation of the HTH motif (not shown).
