Fig. 4.

Microbes drive inflammation in KO mice. Fecal lipocalin-2 (number of mice indicated on graph, data pooled from two independent experiments) (A), summary data (B), and representative images of rectum crypt length (C) in WT and KO mice treated with NMVA antibiotics or untreated for 4 wk beginning at 2 mo of age (n = 4–6 mice per group, 20 individual measurements/region per mouse for each replicate value); *P ≤ 0.05, ****P ≤ 0.0001 from two-way ANOVA with Sidak’s post hoc test for multiple comparisons (A and B). ns, not significant. (Scale bars: 500 μM.)