Fig. 5.

Cosmc regionally regulates the gut microbiota community structure. (A and B) The microbiota was harvested from the gut lumen (distal colon) and mucosa (distal colon, ileum) from KO and WT mice for amplification of the V4 region and 16S rRNA gene sequencing (n = 7–8 mice per group, 2 mo old). Microbiota composition at the order (A) and genus (B) levels were plotted for all regions. Only colon mucosa contained significantly altered taxa (indicated with asterisks); ****P ≤ 0.0001 from two-way ANOVA with Sidak post hoc test for multiple comparisons.