Fig. S8.

Cosmc controls diverse host pathways that regulate the microbiota and inflammation in the distal colon. Epithelial cells were purified from the CR or SI from KO and WT mice, and gene expression was performed on Illumina mouse ref 8 v2.0 expression chip. (A) Heat map indicating genes significantly altered by Cosmc KO (n = 4 mice per group, age 2 mo; fold change > 1.5, FDR < 0.05). (B) The number of genes altered in only CR, SI, or both are indicated with the most relevant gene sets from C or individual genes from E bulleted. No change in ST6GALNAC1 was seen. (C) Metacore GSEA was performed on CR and SI for gene sets enriched for diseases or GO processes. (D) Ingenuity pathway analysis used for gene expression from KO and WT epithelia isolated from colorectum. (E) Expression of individual IBD or antimicrobial genes from the CR as determined from the expression array.