Table S1.
Top 10 Reactome pathways enriched among the genes up-regulated >50% in Cbl, Cbl-b dKD MCF10A cells over control cells
| Term | Overlap | P value | Adjusted P value | Z-score | Combined score |
| Unfolded protein response (UPR) | 15/79 | 1.83809E-11 | 9.20884E-09 | −1.946148267 | 36.0097789 |
| IRE1α activates chaperones | 10/48 | 2.36377E-08 | 5.92124E-06 | −1.930889588 | 23.24205058 |
| XBP1(S) activates chaperone genes | 9/46 | 1.97574E-07 | 3.29948E-05 | −1.888849525 | 19.49133983 |
| ATF6-α activates chaperones | 5/12 | 5.53459E-06 | 0.000554566 | −1.736535884 | 13.01937413 |
| ATF6-α activates chaperone genes | 5/10 | 2.75676E-06 | 0.000345284 | −1.531439766 | 12.20732616 |
| PERK regulates gene expression | 4/28 | 0.001683934 | 0.1406085 | −2.074476627 | 4.069658138 |
| Class I MHC mediated antigen processing and presentation | 10/255 | 0.010818693 | 0.494316978 | −2.151411285 | 1.515837731 |
| SHC1 events in ERBB4 signaling | 3/28 | 0.013553964 | 0.510670007 | −2.213166992 | 1.487318324 |
| GRB2 events in ERBB2 signaling | 3/30 | 0.016070847 | 0.510670007 | −2.124871487 | 1.427980947 |
| SHC1 events in ERBB2 signaling | 3/32 | 0.018832923 | 0.510670007 | −2.115029487 | 1.421366812 |