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Alignment of EhDbr1 and MRE11. (A) Complex of the 7-mer bRNA AK46 with H91A EhDbr1. (B) Mre11 (PDB ID code 1II7) in complex with dAMP. (C) Alignment of Mre11 and EhDbr1. The active sites are similar, including the position of the bridging nucleophile, despite the substitution of the first aspartic acid in the signature MPE sequence for a cysteine.
