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Topical effect of HEVP on mice ear edema induced by five different irritant agents. (A) Croton oil; (B) AA; (C) phenol; (D) EPP; and (E) capsaicin. Bars represent the mean ± S.E.M (n = 8). * p < 0.05, ** p < 0.01 and *** p < 0.001 represent the significance level when compared with negative control group. ANOVA followed by Student-Newman-Keuls test as post hoc.
