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. 2016 Nov 25;17(12):1971. doi: 10.3390/ijms17121971

Figure 3.

Figure 3

LRIP ameliorated histopathological changes and infarct size of the brain. (A) Brain sections of rats in different groups were stained by Hematoxylin and Eosin and then examined using a light microscope. Representative photomicrographs of ischemic cortices from the sham, LRIP, I/R, I/R + 0 h, I/R + 1 h, and I/R + 3 h groups were established. The most significant reversal of injury was observed in the I/R + 0 h group. The magnification was 400×. Scale bar = 50 µm; n = 6; (B) rat brain slices were obtained by making a coronal cut through the optic chiasma. Tissue corresponding to the square icon was used for Hematoxylin and Eosin Staining; (C) histopathological scores of paraffin sections of the rat brain; (D) representative infarcts stained by 2,3,5-triphenyhetrazolium chloride (TTC); (E) bar graphs show the average infarct size of the five slices. Data are expressed as mean ± SD, n = 6, ** p < 0.01 vs. sham group, ## p < 0.01 vs. I/R group.