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. 2016 Nov 25;17(12):1971. doi: 10.3390/ijms17121971

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The Myeloid differentiation factor 88 (MyD88)/Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/p38 mitogen-activated protein kinase (p38-MAPK) signaling pathway is involved in the mechanism through with LRIP protects against I/R injury. Representative images of Western blot assessments and the quantitative analysis of the ratio of: MyD88 (A); TRAF6 (B); and p-p38 MAPK (C). Data are expressed as mean ± SD, n = 3, * p < 0.05 vs. sham group, ** p < 0.01 vs. sham group, ^# p < 0.05 vs. I/R group, ^## p < 0.01 vs. I/R group.