Table 1.
The decreasing amplitude of systolic blood pressure of spontaneously hypertensive rats (SHRs) at different time points after a single oral dose (X ± SD, n = 6) (mmHg).
| Time | Group Control | ||||
|---|---|---|---|---|---|
| Saline Group | 0.4 mg/kg VP5 | 0.8 mg/kg VP5 | 1.6 mg/kg VP5 | 0.8 mg/kg VP5-NPs | |
| 2 h | 4.5 ± 3.2 | 10.0 ± 1.3 *** | 13.4 ± 2.2 *** | 17.7 ± 3.8 *** | 26.7 ± 3.7 *** |
| 4 h | 1.2 ± 0.6 | 5.2 ± 1.9 * | 20.2 ± 3.6 *** | 18.5 ± 5.8 *** | 31.7 ± 2.3 *** |
| 8 h | 1.0 ± 4.7 | 8.2 ± 2.6 | 12.4 ± 2.3 | 20.9 ± 4.2 *** | 28.9 ± 1.9 *** |
| 12 h | 8.2 ± 1.2 | 9.4 ± 1.3 | 15.8 ± 3.7 | 19.5 ± 3.0 *** | 23.6 ± 3.8 *** |
| 24 h | 1.2 ± 1.5 | 1.6 ± 1.6 | 3.5 ± 0.8 | 6.0 ± 3.4 | 21.5 ± 0.7 *** |
| 48 h | 2.2 ± 1.6 | −0.5 ± 1.8 | 2.4 ± 1.2 | 1.5 ± 2.5 | 20.4 ± 1.0 *** |
| 72 h | 0.3 ± 1.5 | −2.7 ± 1.1 | 3.2 ± 1.6 | −0.1 ± 1.0 | 18.7 ± 3.9 *** |
| 96 h | 0.6 ± 0.5 | −2.6 ± 2.7 | 4.4 ± 0.7 | −1.6 ± 1.4 | −0.6 ± 3.5 |
One-way analysis of variance was used for calculating statistical significance, which was set at * p < 0.05, *** p < 0.01. VP5-NPs and three crude VP5 groups versus control group.