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. 2016 Dec 1;17(12):2011. doi: 10.3390/ijms17122011

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A,C) No differences in staining patterns of YO-PRO, Hoechst and propidium iodide (PI) were observed after 24 h of sorafenib treatment in Caco-2 and after 48 h in HRT-18 cells and (B,D) A shift towards the S-phase in cell cycle was observed with increasing concentrations of sorafenib for both cell lines. *, **, *** indicate values significantly (p < 0.05), highly significantly (p < 0.01) or (p < 0.001) different from the solvent control, respectively (two-sided, unpaired t-test); untreated DMSO control indicates untreated cell samples.