Table 3.
Comparison of genotype frequencies of PAI-1 gene haplotype between the osteoporosis, non-OVCF, OVCF patients and control subjects.
| Haplotype | Overall (n = 355) | Control (n = 197) | Case (n = 158) | OR (95% CI) | p a | Non-OVCF (n = 71) | OR (95% CI) | p a | OVCF (n = 87) | OR (95% CI) | p a |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PAI-1 −844/−675/+43/+9785/+11053 | - | - | - | - | - | - | - | - | - | ||
| G-4G-G-G-T | 0.179 | 0.237 | 0.098 | 1.000 (reference) | - | 0.107 | 1.000 (reference) | - | 0.133 | 1.000 (reference) | - |
| G-4G-G-G-G | 0.092 | 0.099 | 0.092 | 2.231 (1.189–4.187) | 0.015 | 0.127 | 2.862 (1.311–6.247) | 0.013 | 0.099 | 1.763 (0.849–3.658) | 0.177 |
| G-4G-G-A-T | 0.008 | 0.019 | 0.000 | 0.198 (0.011–3.567) | 0.197 | 0.000 | 0.402 (0.022–7.408) | 0.592 | 0.002 | 0.265 (0.015–4.816) | 0.346 |
| G-4G-G-A-G | 0.006 | 0.007 | 0.000 | 0.424 (0.023–8.443) | 1.000 | 0.000 | 0.862 (0.042–17.52) | 1.000 | 0.015 | 4.043 (0.765–21.36) | 0.110 |
| G-4G-A-G-T | 0.007 | 0.000 | 0.032 | 62.33 (3.547–109.5) | <0.0001 | 0.008 | 18.10 (0.704–465.0) | 0.147 | 0.012 | 19.89 (0.923–428.8) | 0.044 |
| G-4G-A-G-G | 0.021 | 0.007 | 0.025 | 8.000 (1.996–32.06) | 0.002 | 0.000 | 0.862 (0.042–17.52) | 1.000 | 0.000 | 0.568 (0.028–11.40) | 1.000 |
| G-4G-A-A-T | 0.004 | 0.000 | 0.004 | 8.905 (0.353–224.4) | 0.256 | 0.000 | N/A | - | 0.006 | 11.94 (0.471–302.7) | 0.205 |
| G-5G-G-G-T | 0.157 | 0.158 | 0.168 | 2.565 (1.483–4.434) | 0.001 | 0.173 | 2.500 (1.221–5.118) | 0.013 | 0.140 | 1.565 (0.812–3.017) | 0.184 |
| G-5G-G-G-G | 0.029 | 0.018 | 0.043 | 5.571 (2.039–15.22) | 0.001 | 0.047 | 6.200 (1.903–20.20) | 0.004 | 0.058 | 5.776 (1.984–16.82) | 0.001 |
| G-5G-G-A-T | 0.009 | 0.006 | 0.000 | 0.594 (0.028–12.71) | 1.000 | 0.013 | 6.200 (0.810–47.44) | 0.109 | 0.004 | 2.022 (0.176–23.29) | 0.495 |
| G-5G-G-A-G | 0.002 | 0.003 | 0.000 | 0.989 (0.039–24.93) | 1.000 | 0.001 | 2.011 (0.078–51.66) | 1.000 | 0.001 | 1.326 (0.052–33.63) | 1.000 |
| G-5G-A-G-T | 0.042 | 0.027 | 0.062 | 5.455 (2.353–12.64) | <0.0001 | 0.067 | 5.636 (2.042–15.56) | 0.001 | 0.061 | 4.043 (1.560–10.48) | 0.006 |
| G-5G-A-G-G | 0.007 | 0.003 | 0.007 | 6.000 (0.526–68.51) | 0.165 | 0.001 | 2.011 (0.078–51.66) | 1.000 | 0.001 | 1.326 (0.052–33.63) | 1.000 |
| G-5G-A-A-T | 0.000 | 0.003 | 0.000 | 0.989 (0.039–24.93) | 1.000 | 0.001 | 2.011 (0.078–51.66) | 1.000 | 0.001 | 1.326 (0.052–33.63) | 1.000 |
| A-4G-G-G-T | 0.062 | 0.076 | 0.056 | 1.800 (0.883–3.668) | 0.132 | 0.079 | 2.273 (0.943–5.483) | 0.089 | 0.028 | 0.674 (0.236–1.928) | 0.621 |
| A-4G-G-G-G | 0.310 | 0.311 | 0.283 | 2.195 (1.346–3.580) | 0.002 | 0.361 | 2.571 (1.361–4.855) | 0.004 | 0.329 | 1.874 (1.077–3.261) | 0.032 |
| A-4G-G-A-T | 0.006 | 0.003 | 0.005 | 6.000 (0.526–68.51) | 0.165 | 0.008 | 6.200 (0.368–104.6) | 0.271 | 0.010 | 8.087 (0.702–93.16) | 0.111 |
| A-4G-A-G-T | 0.009 | 0.003 | 0.000 | 0.989 (0.039–24.93) | 1.000 | 0.001 | 2.011 (0.078–51.66) | 1.000 | 0.001 | 1.326 (0.052–33.63) | 1.000 |
| A-4G-A-G-G | 0.014 | 0.003 | 0.046 | 45.00 (5.706–354.9) | <0.0001 | 0.001 | 2.011 (0.078–51.66) | 1.000 | 0.001 | 1.326 (0.052–33.63) | 1.000 |
| A-5G-G-G-T | 0.011 | 0.000 | 0.020 | 38.59 (2.112–705.1) | 0.0004 | 0.000 | N/A | - | 0.076 | 107.4 (6.156–1875) | <0.0001 |
| A-5G-G-G-G | 0.011 | 0.018 | 0.006 | 0.857 (0.169–4.347) | 1.000 | 0.000 | 0.402 (0.022–7.408) | 0.592 | 0.011 | 1.155 (0.225–5.937) | 1.000 |
| A-5G-A-G-T | 0.013 | 0.000 | 0.029 | 56.40 (3.188–997.7) | <0.0001 | 0.010 | 18.100 (0.704–465.0) | 0.147 | 0.013 | 19.89 (0.923–428.8) | 0.044 |
a Fisher’s exact test. N/A, not applicable.