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Autophagic cell death and its regulation by p53. Nuclear p53 induces autophagic cell death by transcriptionally upregulating tuberous sclerosis (TSC2), AMP-activated protein kinase (AMPK), and damage-regulated autophagy modulator (DRAM), whereas cytoplasmic p53 inhibits autophagic cell death by inducing Beclin-1 degradation. mTOR: mammalian target of rapamycin.
