Figure 1.

Schematic overview of X chromosome and distribution of mutations in g6pd gene coding sequence. The top shown the introns and exons that are shown in gray and pink color boxes, respectively. The numbers (1–13) indicate exons of the human g6pd gene. In the bottom, the mRNA is schematized and all the single nucleotide substitutions (missense variants) are showed. The red circles are mutations associated with chronic nonspherocytic hemolytic anemia. Purple circles showed the Class II mutations. Class III mutations are shown in yellow circles. Class IV mutations are shown in brown circles and the unnamed reported class mutations are shown in bright green circles.