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Structure of human WT G6PD enzyme (PDB entries 2BHL and 2BH9) indicating the location of Class I mutations in the dimer. Note that all mutations are located on equivalent positions of G6PD dimer. Right inset, close-up of Class I (red spheres) mutations located in both the dimer interface and near the structural NADP+ molecules. The figure was prepared using CCP4mg [28].
