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. 2016 Dec 13;17(12):2086. doi: 10.3390/ijms17122086

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene set pathway enrichment analysis of ethinyl estradiol responsive E2 and NRF1 common target genes associated with Alzheimer’s Disease (AD). The network includes the top 30 ethinyl estradiol-associated genes in AD in gray. Ethinyl estradiol responsive NRF1 genes are in black and * genes denoted by a diamond-shaped node are E2 and NRF1. Right panel show GO annotations of E2 and NRF1 enrichment network genes of ethinyl estradiol associated with biological process pathways involving multiple E2 and NRF1 genes and Q-value as a probability showing number of genes out of the total genes annotated to each GO term.