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Potential action mechanism of T-DM1. (A) Trastuzumab specifically recognizes and binds to extracellular domain of HER2; (B) induced passive endocytosis of the formed complex of trastuzumab and HER2; (C) the complex may undergo a degradation process to separate the DM-1 from the complex; and (D) the liberated DM-1 exerts its cytotoxicity on the microtubule. Modified based on the work contributed by Martinez et al. [94].
