Table 2.
Distinct splicing factors modulate a set of apoptosis-related alternative splicing (AS) events.
| Splicing Regulator | Specific Candidate | Impact on AS | Biological Signatures | Reference |
|---|---|---|---|---|
| SRSF1 | INSR | Exon 11 inclusion (INSR-B) | anti-apoptosis | [115,116,117] |
| CASC4 | Exon 9 inclusion | anti-apoptosis | ||
| SRSF3 | Casp2 | Exon 9 skipping | anti-apoptosis | [109,110,111,112,113] |
| HIPK2 | Alternative 3′ SS selection (Exon 8) | pro-apoptosis | ||
| PDCD4 | Intron retention (Intron 3) | anti-apoptosis | ||
| HnRNP A1 | Fas | Exon 6 inclusion | anti-apoptosis | [121] |
| HnRNP K | Bcl-x | Authentic 5' SS selection (Bcl-xL) | anti-apoptosis | [122,123,124] |
| HnRNP I | Mcl-1 | Exon 2 inclusion (Mcl-1L) | anti-apoptosis | [126] |
| Bim | Exon 4 inclusion | anti-apoptosis | [101] | |
| RBM4 | Bcl-x | Alternative 5′ SS selection (Bcl-xS) | pro-apoptosis | [95] |
| Mcl-1 | Exon 2 skipping (Mcl-1S) | pro-apoptosis | [131] | |
| RBM5/10 | c-FLIP | Alternative 5′ SS selection | anti-apoptosis (c-FLIPS) | [129] |
| Fas | Exon 6 skipping | anti-apoptosis | [134] | |
| Casp2 | Exon 9 inclusion | pro-apoptosis | [133] | |
| NUMB | Exon 9 inclusion/exclusion | uncharacterized | [132] |